what is Phentermine 37.5 mg?
Phentermine 37.5 mg is a prescription weight loss medication.
It was approved by the FDA in 1959 for short-term use of up to 12 weeks for people older than 16 (1Trusted Source).
In the 1990s, Phentermine 37.5 mg was combined with other weight loss drugs. This drug combination was commonly called fen-phen.
After reports of significant heart problems in users, the FDA pulled the other two drugs used in the treatment — fenfluramine and dexfenfluramine — from the market (2Trusted Source).
Phentermine 37.5 mg goes by the brand names Adipex-P, Lomaira, and Suprenza, or you can find it in combination medications for weight loss, such as Qsymia.
how does it work?
Phentermine 37.5 mg belongs to a class of drugs called “anorectics,” also known as appetite suppressants.
Taking Phentermine 37.5 mg helps suppress your appetite, thereby limiting how many calories you eat. Over time, this can lead to weight loss
While the exact mechanisms behind the appetite-reducing effects of phentermine remain unclear, the drug is thought to act by increasing neurotransmitter levels in your brain (6Trusted Source, 7Trusted Source).
Neurotransmitters are your body’s chemical messengers and include norepinephrine, serotonin, and dopamine.
When your levels of these three chemicals increase, your feeling of hunger decreases.
However, you may build a tolerance to the appetite-suppressing effects of phentermine within a few weeks. In that case, you should not increase your dose of the drug but stop using it altogether.
how effective it is?
Several clinical studies have proven that Phentermine 37.5 mg can boost fat loss.
The expected average weight loss with phentermine use is 5% of your initial body weight. Yet, over 12 weeks, it can be as high as 10%. This equates to a weight loss of 10–20 pounds (4.5–9 kg) for a 200 pound (90.7 kg) person (8Trusted Source).
In a meta-analysis of six studies, people who took the average dose of 27.5 mg of Phentermine 37.5 mg for 13 weeks lost an average of 13.9 pounds (6.3 kg) compared to 6.2 pounds (2.8 kg) in placebo groups (9Trusted Source).
While Phentermine 37.5 mg has been shown to be effective for weight loss, it may work better when combined with topiramate (10Trusted Source).
Topiramate is a drug that has been used on its own to treat seizures but — like Phentermine 37.5 mg — also has appetite-reducing properties (11Trusted Source, 12Trusted Source, 13Trusted Source).
Topiramate and Phentermine 37.5 mg is a combination medication sold under the brand name Qsymia.
Compared to three other commonly prescribed drugs for weight loss, the combination of Phentermine 37.5 mg and topiramate was associated with the highest odds of losing at least 5% of the initial body weight (14Trusted Source).
What’s more, research suggests that the Phentermine and topiramate combination is the most effective weight loss medication to date — with people achieving an average weight loss of 21.6 pounds (9.8 kg) after taking the maximum dose for one year (15Trusted Source).
In users, this weight loss has translated to a significant decrease in waist circumference, improved insulin sensitivity, and blood sugar control, as well as favorable effects on triglyceride and cholesterol levels (16Trusted Source, 17Trusted Source).
It is not known if Suprenza is excreted in human milk; however, other amphetamines are present
in human milk. Because of the potential for serious adverse reactions in nursing infants, a
decision should be made whether to discontinue nursing or to discontinue the drug, taking into
account the importance of the drug to the mother.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end
of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac
function, and of concomitant disease or other drug therapy.
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to
this drug may be greater in patients with impaired renal function. Because elderly patients are
more likely to have decreased renal function, care should be taken in dose selection, and it may
be useful to monitor renal function.
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